AustralieFrV1, Main, Exploration, bibRecord, 000413

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Identifieur interne : 000413 ( Main/Exploration ); précédent : 000412; suivant : 000414

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Auteurs : Elizabeth M. Swisher [États-Unis] ; Kevin K. Lin [États-Unis] ; Amit M. Oza [Canada] ; Clare L. Scott [Australie] ; Heidi Giordano [États-Unis] ; James Sun [États-Unis] ; Gottfried E. Konecny [États-Unis] ; Robert L. Coleman [États-Unis] ; Anna V. Tinker [Canada] ; David M. O'Malley [États-Unis] ; Rebecca S. Kristeleit [Royaume-Uni] ; Ling Ma [États-Unis] ; Katherine M. Bell-Mcguinn [États-Unis] ; James D. Brenton [Royaume-Uni] ; Janiel M. Cragun [États-Unis] ; Ana Oaknin [Espagne] ; Isabelle Ray-Coquard [France] ; Maria I. Harrell [États-Unis] ; Elaina Mann [États-Unis] ; Scott H. Kaufmann [États-Unis] ; Anne Floquet [France] ; Alexandra Leary [France] ; Thomas C. Harding [États-Unis] ; Sandra Goble [États-Unis] ; Lara Maloney [États-Unis] ; Jeff Isaacson [États-Unis] ; Andrew R. Allen [États-Unis] ; Lindsey Rolfe [États-Unis] ; Roman Yelensky [États-Unis] ; Mitch Raponi [États-Unis] ; Iain A. Mcneish [Royaume-Uni]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2017.

RBID : pubmed:27908594

Descripteurs français

English descriptors

KwdEn :
- Aged, Antineoplastic Agents (pharmacology), BRCA1 Protein (genetics), BRCA2 Protein (genetics), Drug Resistance, Neoplasm (drug effects), Fallopian Tube Neoplasms (drug therapy), Fallopian Tube Neoplasms (genetics), Fallopian Tube Neoplasms (pathology), Female, Follow-Up Studies, Germ-Line Mutation (genetics), Humans, Indoles (therapeutic use), International Agencies, Middle Aged, Neoplasm Recurrence, Local (drug therapy), Neoplasm Recurrence, Local (genetics), Neoplasm Recurrence, Local (pathology), Neoplasm Staging, Neoplasms, Glandular and Epithelial (drug therapy), Neoplasms, Glandular and Epithelial (genetics), Neoplasms, Glandular and Epithelial (pathology), Ovarian Neoplasms (drug therapy), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Peritoneal Neoplasms (drug therapy), Peritoneal Neoplasms (genetics), Peritoneal Neoplasms (pathology), Platinum (pharmacology), Poly(ADP-ribose) Polymerase Inhibitors (therapeutic use), Poly(ADP-ribose) Polymerases (chemistry), Prognosis, Prospective Studies, Salvage Therapy, Survival Rate.
MESH :
- chemical , chemistry : Poly(ADP-ribose) Polymerases.
- chemical , genetics : BRCA1 Protein, BRCA2 Protein.
- chemical , pharmacology : Antineoplastic Agents, Platinum.
- drug effects : Drug Resistance, Neoplasm.
- drug therapy : Fallopian Tube Neoplasms, Neoplasm Recurrence, Local, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Peritoneal Neoplasms.
- genetics : Fallopian Tube Neoplasms, Germ-Line Mutation, Neoplasm Recurrence, Local, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Peritoneal Neoplasms.
- pathology : Fallopian Tube Neoplasms, Neoplasm Recurrence, Local, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Peritoneal Neoplasms.
- chemical , therapeutic use : Indoles, Poly(ADP-ribose) Polymerase Inhibitors.
- Aged, Female, Follow-Up Studies, Humans, International Agencies, Middle Aged, Neoplasm Staging, Prognosis, Prospective Studies, Salvage Therapy, Survival Rate.

Abstract

Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous recombination deficiency. In ARIEL2, we assessed the ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor.

DOI: 10.1016/S1470-2045(16)30559-9
PubMed: 27908594

Affiliations:

Le document en format XML

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<author><name sortKey="Tinker, Anna V" sort="Tinker, Anna V" uniqKey="Tinker A" first="Anna V" last="Tinker">Anna V. Tinker</name>
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<author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M" last="O'Malley">David M. O'Malley</name>
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<author><name sortKey="Kristeleit, Rebecca S" sort="Kristeleit, Rebecca S" uniqKey="Kristeleit R" first="Rebecca S" last="Kristeleit">Rebecca S. Kristeleit</name>
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<author><name sortKey="Ma, Ling" sort="Ma, Ling" uniqKey="Ma L" first="Ling" last="Ma">Ling Ma</name>
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<author><name sortKey="Cragun, Janiel M" sort="Cragun, Janiel M" uniqKey="Cragun J" first="Janiel M" last="Cragun">Janiel M. Cragun</name>
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<author><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name>
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<author><name sortKey="Harrell, Maria I" sort="Harrell, Maria I" uniqKey="Harrell M" first="Maria I" last="Harrell">Maria I. Harrell</name>
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<author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name>
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<author><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name>
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<author><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C" last="Harding">Thomas C. Harding</name>
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<author><name sortKey="Goble, Sandra" sort="Goble, Sandra" uniqKey="Goble S" first="Sandra" last="Goble">Sandra Goble</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Isaacson, Jeff" sort="Isaacson, Jeff" uniqKey="Isaacson J" first="Jeff" last="Isaacson">Jeff Isaacson</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
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<author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yelensky, Roman" sort="Yelensky, Roman" uniqKey="Yelensky R" first="Roman" last="Yelensky">Roman Yelensky</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Foundation Medicine, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A" last="Mcneish">Iain A. Mcneish</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.</title>
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</placeName>
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<author><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name>
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<country xml:lang="fr">Canada</country>
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<wicri:noRegion>ON</wicri:noRegion>
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<author><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L" last="Scott">Clare L. Scott</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal Melbourne Hospital, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
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<author><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name>
<affiliation wicri:level="2"><nlm:affiliation>Foundation Medicine, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Foundation Medicine, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Konecny, Gottfried E" sort="Konecny, Gottfried E" uniqKey="Konecny G" first="Gottfried E" last="Konecny">Gottfried E. Konecny</name>
<affiliation wicri:level="2"><nlm:affiliation>University of California Los Angeles, Santa Monica, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California Los Angeles, Santa Monica, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tinker, Anna V" sort="Tinker, Anna V" uniqKey="Tinker A" first="Anna V" last="Tinker">Anna V. Tinker</name>
<affiliation wicri:level="1"><nlm:affiliation>British Columbia Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>British Columbia Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M" last="O'Malley">David M. O'Malley</name>
<affiliation wicri:level="2"><nlm:affiliation>The Ohio State University, James Cancer Center, Columbus, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Ohio State University, James Cancer Center, Columbus, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kristeleit, Rebecca S" sort="Kristeleit, Rebecca S" uniqKey="Kristeleit R" first="Rebecca S" last="Kristeleit">Rebecca S. Kristeleit</name>
<affiliation wicri:level="4"><nlm:affiliation>University College London, Cancer Institute, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University College London, Cancer Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Ma, Ling" sort="Ma, Ling" uniqKey="Ma L" first="Ling" last="Ma">Ling Ma</name>
<affiliation wicri:level="2"><nlm:affiliation>Rocky Mountain Cancer Centers, Lakewood, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rocky Mountain Cancer Centers, Lakewood, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bell Mcguinn, Katherine M" sort="Bell Mcguinn, Katherine M" uniqKey="Bell Mcguinn K" first="Katherine M" last="Bell-Mcguinn">Katherine M. Bell-Mcguinn</name>
<affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Sloan-Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brenton, James D" sort="Brenton, James D" uniqKey="Brenton J" first="James D" last="Brenton">James D. Brenton</name>
<affiliation wicri:level="4"><nlm:affiliation>Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cragun, Janiel M" sort="Cragun, Janiel M" uniqKey="Cragun J" first="Janiel M" last="Cragun">Janiel M. Cragun</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Arizona Cancer Center, Tucson, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Arizona Cancer Center, Tucson, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name>
<affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name>
<affiliation wicri:level="3"><nlm:affiliation>GINECO, Centre Léon Bérard and University Claude Bernard, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>GINECO, Centre Léon Bérard and University Claude Bernard, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrell, Maria I" sort="Harrell, Maria I" uniqKey="Harrell M" first="Maria I" last="Harrell">Maria I. Harrell</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Mann, Elaina" sort="Mann, Elaina" uniqKey="Mann E" first="Elaina" last="Mann">Elaina Mann</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaufmann, Scott H" sort="Kaufmann, Scott H" uniqKey="Kaufmann S" first="Scott H" last="Kaufmann">Scott H. Kaufmann</name>
<affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Bergonié, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Bergonié, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name>
<affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy Cancer Center and INSERM U981, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy Cancer Center and INSERM U981, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C" last="Harding">Thomas C. Harding</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goble, Sandra" sort="Goble, Sandra" uniqKey="Goble S" first="Sandra" last="Goble">Sandra Goble</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Isaacson, Jeff" sort="Isaacson, Jeff" uniqKey="Isaacson J" first="Jeff" last="Isaacson">Jeff Isaacson</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rolfe, Lindsey" sort="Rolfe, Lindsey" uniqKey="Rolfe L" first="Lindsey" last="Rolfe">Lindsey Rolfe</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yelensky, Roman" sort="Yelensky, Roman" uniqKey="Yelensky R" first="Roman" last="Yelensky">Roman Yelensky</name>
<affiliation wicri:level="2"><nlm:affiliation>Foundation Medicine, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Foundation Medicine, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name>
<affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A" last="Mcneish">Iain A. Mcneish</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Oncology</title>
<idno type="eISSN">1474-5488</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>BRCA1 Protein (genetics)</term>
<term>BRCA2 Protein (genetics)</term>
<term>Drug Resistance, Neoplasm (drug effects)</term>
<term>Fallopian Tube Neoplasms (drug therapy)</term>
<term>Fallopian Tube Neoplasms (genetics)</term>
<term>Fallopian Tube Neoplasms (pathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Germ-Line Mutation (genetics)</term>
<term>Humans</term>
<term>Indoles (therapeutic use)</term>
<term>International Agencies</term>
<term>Middle Aged</term>
<term>Neoplasm Recurrence, Local (drug therapy)</term>
<term>Neoplasm Recurrence, Local (genetics)</term>
<term>Neoplasm Recurrence, Local (pathology)</term>
<term>Neoplasm Staging</term>
<term>Neoplasms, Glandular and Epithelial (drug therapy)</term>
<term>Neoplasms, Glandular and Epithelial (genetics)</term>
<term>Neoplasms, Glandular and Epithelial (pathology)</term>
<term>Ovarian Neoplasms (drug therapy)</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Ovarian Neoplasms (pathology)</term>
<term>Peritoneal Neoplasms (drug therapy)</term>
<term>Peritoneal Neoplasms (genetics)</term>
<term>Peritoneal Neoplasms (pathology)</term>
<term>Platinum (pharmacology)</term>
<term>Poly(ADP-ribose) Polymerase Inhibitors (therapeutic use)</term>
<term>Poly(ADP-ribose) Polymerases (chemistry)</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Salvage Therapy</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Agences internationales</term>
<term>Antinéoplasiques (pharmacologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indoles (usage thérapeutique)</term>
<term>Inhibiteurs de poly(ADP-ribose) polymérases (usage thérapeutique)</term>
<term>Mutation germinale (génétique)</term>
<term>Platine (pharmacologie)</term>
<term>Poly(ADP-ribose) polymerases ()</term>
<term>Pronostic</term>
<term>Protéine BRCA1 (génétique)</term>
<term>Protéine BRCA2 (génétique)</term>
<term>Récidive tumorale locale (anatomopathologie)</term>
<term>Récidive tumorale locale (génétique)</term>
<term>Récidive tumorale locale (traitement médicamenteux)</term>
<term>Résistance aux médicaments antinéoplasiques ()</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Taux de survie</term>
<term>Thérapie de rattrapage</term>
<term>Tumeurs de l'ovaire (anatomopathologie)</term>
<term>Tumeurs de l'ovaire (génétique)</term>
<term>Tumeurs de l'ovaire (traitement médicamenteux)</term>
<term>Tumeurs de la trompe de Fallope (anatomopathologie)</term>
<term>Tumeurs de la trompe de Fallope (génétique)</term>
<term>Tumeurs de la trompe de Fallope (traitement médicamenteux)</term>
<term>Tumeurs du péritoine (anatomopathologie)</term>
<term>Tumeurs du péritoine (génétique)</term>
<term>Tumeurs du péritoine (traitement médicamenteux)</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires (anatomopathologie)</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires (génétique)</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires (traitement médicamenteux)</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Poly(ADP-ribose) Polymerases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>BRCA1 Protein</term>
<term>BRCA2 Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Platinum</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Récidive tumorale locale</term>
<term>Tumeurs de l'ovaire</term>
<term>Tumeurs de la trompe de Fallope</term>
<term>Tumeurs du péritoine</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Neoplasm</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Fallopian Tube Neoplasms</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasms, Glandular and Epithelial</term>
<term>Ovarian Neoplasms</term>
<term>Peritoneal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fallopian Tube Neoplasms</term>
<term>Germ-Line Mutation</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasms, Glandular and Epithelial</term>
<term>Ovarian Neoplasms</term>
<term>Peritoneal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation germinale</term>
<term>Protéine BRCA1</term>
<term>Protéine BRCA2</term>
<term>Récidive tumorale locale</term>
<term>Tumeurs de l'ovaire</term>
<term>Tumeurs de la trompe de Fallope</term>
<term>Tumeurs du péritoine</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fallopian Tube Neoplasms</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasms, Glandular and Epithelial</term>
<term>Ovarian Neoplasms</term>
<term>Peritoneal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Platine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indoles</term>
<term>Poly(ADP-ribose) Polymerase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Récidive tumorale locale</term>
<term>Tumeurs de l'ovaire</term>
<term>Tumeurs de la trompe de Fallope</term>
<term>Tumeurs du péritoine</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Indoles</term>
<term>Inhibiteurs de poly(ADP-ribose) polymérases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>International Agencies</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Salvage Therapy</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Agences internationales</term>
<term>Femelle</term>
<term>Humains</term>
<term>Poly(ADP-ribose) polymerases</term>
<term>Pronostic</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Taux de survie</term>
<term>Thérapie de rattrapage</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous recombination deficiency. In ARIEL2, we assessed the ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Aquitaine</li>
<li>Arizona</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Colorado</li>
<li>Grand Londres</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Nouvelle-Aquitaine</li>
<li>Ohio</li>
<li>Rhône-Alpes</li>
<li>Texas</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>État de New York</li>
</region>
<settlement><li>Barcelone</li>
<li>Bordeaux</li>
<li>Cambridge</li>
<li>Glasgow</li>
<li>Londres</li>
<li>Lyon</li>
<li>Seattle</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de Cambridge</li>
<li>Université de Glasgow</li>
<li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Swisher, Elizabeth M" sort="Swisher, Elizabeth M" uniqKey="Swisher E" first="Elizabeth M" last="Swisher">Elizabeth M. Swisher</name>
</region>
<name sortKey="Allen, Andrew R" sort="Allen, Andrew R" uniqKey="Allen A" first="Andrew R" last="Allen">Andrew R. Allen</name>
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Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000413 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27908594
   |texte=   Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
}}

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       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

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English descriptors

Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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